Balancing Nature with Science to Produce
Safe & Effective Innovative Therapies
with Targeted Selective Properties

Se-cure is a research-driven pharmaceutical company founded in 1997, which has developed a proprietary platform for the discovery, development and scaling of therapies from botanical origin.

Implementing proprietary botanical therapies development and scaling technologies, Se-cure introduces novel biochemical agents characterized by functionally selective mechanisms of action in target tissues providing safe and effective solutions to medical needs.

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Endorsed by the Medical Societies as 1st Line Treatment

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OUR
TECHNOLOGY
Developing Innovative Botanical Therapies

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Standardization of the Proprietary APIs

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Our expertise lies in the development of proprietary botanical therapies using the unique properties in the plant origin to create innovative APIs that have the ability to selectively target specific tissues, without affecting unwanted tissues and thus, develop safe and effective therapies that can be used for the long-term without imposing risks on the users.

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Standardization is a major challenge in developing therapies from a botanical source. In the development of botanical APIs multiple variables come into play which require monitoring and control to secure standardization.
Se-cure applies an integrated methodology to guarantee product standardization and batch to batch therapeutic consistency.

In a cGMP production facility, Se-cure practices its multi-layer standardization control methodology:

Raw material standardization – a proprietary process developed in house, stabilizing the botanical raw material from yield to yield, providing API consistency with a clear fingerprint.

In-line controls – analytical tools monitor consistency of formulations while in process, and bio-chemical tools monitor the presence of residuals and microorganisms.

Finished product controls – analytical tools are used for the finished product release criteria.

 

Se-cure’s stringent botanical API and finished product’s specifications and controls, ensure the highest quality of its products.

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OUR
TECHNOLOGY
Developing Innovative Botanical Therapies

Read more

Artboard 1

Our expertise lies in the development of proprietary botanical therapies using the unique properties in the plant origin to create innovative APIs that have the ability to selectively target specific tissues, without affecting unwanted tissues and thus, develop safe and effective therapies that can be used for the long-term without imposing risks on the users.

Close

Standardization of the Proprietary APIs

Read more

Artboard 1

Standardization is a major challenge in developing therapies from a botanical source. In the development of botanical APIs multiple variables come into play which require monitoring and control to secure standardization.
Se-cure applies an integrated methodology to guarantee product standardization and batch to batch therapeutic consistency.

In a cGMP production facility, Se-cure practices its multi-layer standardization control methodology:

Raw material standardization – a proprietary process developed in house, stabilizing the botanical raw material from yield to yield, providing API consistency with a clear fingerprint.

In-line controls – analytical tools monitor consistency of formulations while in process, and bio-chemical tools monitor the presence of residuals and microorganisms.

Finished product controls – analytical tools are used for the finished product release criteria.

 

Se-cure’s stringent botanical API and finished product’s specifications and controls, ensure the highest quality of its products.

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    PRODUCTS IN THE MARKET
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    Brizo®

    Targets Men's Urinary Health. Urinary urgency and overactive bladder symptoms affect more than half the population of men in their 50's and this percentage grows to as many as 90% of men in their 70's.

    Being the most common form of ailment, an overactive bladder leads to bothersome urinary symptoms affecting men’s life both during the day and night, and considerably impacts men’s quality of life.

    The most common cause of overactive bladder symptoms in men is the enlargement of the prostate as men age.

    Brizo® is intended for all men who suffer from irritable lower urinary tract issues associated with the aging of the prostate gland.

    The API in Brizo®, SC012 originates from the soybean plant undergoing a unique process, creating a substance that selectively targets the prostate gland itself targeting several pathways that are at the base of the enlargement of the prostate which leads to urinary symptoms without leading to any unwanted effects.

    SC012 selectively activates and bonds to ERβ (agonistic activity) while restraining the stimulatory action of ERα (antagonist activity), this process controls prostatic growth. In addition, SC012 bonds and blocks Androgen Receptors (antagonistic effect), blocking the ability of Dihydrotestosterone (DHT) to attach to the AR and encourage prostate proliferation.

    This combined mechanism provides a significant relief of the bothersome urinary symptoms within the 1st month of use, felt by the lessening of the urge to urinate during the day and night.

    For more information you are invited to visit: www.brizo-bph.com

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    Fermarelle®

    Our first line of products targets Women Healthcare, providing women risk free, effective solutions for the management of their post-reproductive life.

    The decline in estrogen levels starting in women’s 40s, leads to a chronic hormonal imbalance affecting women from this stage onwards. This change dramatically impacts women’s quality of life, from the onset of ‘menopausal’ symptoms to the progression of post-menopausal diseases.

    The Femarelle® line provides a targeted solution to the needs of the woman:

    • Femarelle® Rejuvenate is indicated for the primary transition of estrogen decline- targeting women 40+.
    • Femarelle® Recharge is indicated for the classical menopause transition- targeting women 50+.
    • Femarelle® Unstoppable is indicated for the more mature women- targeting women 60+.

    The API developed in-house- DT56a is at the core of each product in the line, targeting the estrogen receptors while each product contains different vitamins and minerals, boosting the beneficial impact on the target tissue.

    DT56a, is a non-hormonal proprietary API, originating from the soybean plant, processing the 20 amino acids within the soybean, creating, a unique compound that has been modulated to form the desired effect within the woman’s body, by bonding to the estrogen receptors without being recognized by the body as estrogen, thus developing a non-hormonal botanical therapy that was declared in 2017 as the 1st line treatment for the management of menopause at the European Society of Gynecology.

    DT56a, a standardized compound with a clear fingerprint, mimics the structures that are recognized by estrogen receptors in the woman’s body as estrogen, bound together with either a co-activator or co-repressor, depending on the tissue forming a SERM (Selective Estrogen Receptor Modulator), having either an agonistic (activation) or antagonistic (blocking) effect on the estrogen receptors, depending on the target tissue.

    femarelle picture

     

    In the tissues where we want to motivate estrogen receptor activation, such as the brain and the bone, DT56a mimics the bond of estrogen with a specific co-activator, thus providing the benefits of estrogen. Whilst where an activation is not wanted, such as in the breast and uterus, DT56a attaches to the estrogen receptor by mimicking the bond of estrogen to a co-repressor, thus forming a blocking effect, so as not to cause any proliferation in the reproductive tissues, which is not needed any longer.

    This process provides a targeted solution of estrogen receptor bonding, without being recognized by the body as estrogen, thus, providing the benefits of therapy without exposing the body to the risks.

    For more information on the Femarelle line you are invited to visit: www.femarelle.com

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    Burn Management

    Dental Bone Rejuvenation

    Burn Management

    According to the American Burn Association, 500,000 cases of burns are handled by professional service providers each year in the United States, of whom about 40,000 are hospitalized. The number of minor and medium burns treated by US health and emergency services is estimated to be 2 million cases per year.

    An undesired common phenomenon in cases of burns is the formation of Stasis (cessation of blood flow) around the area of the burn, which occurs for the most part in events of 2nd degree burns extending over a large area and in all 3rd degree burns. The scientific explanation for this phenomenon is that this is a natural process in which the body recognizes the wound of the burn injury as a significant potential risk. For this reason, the skin tissue mortality becomes twice the area of the burn itself, creating significant damage beyond the original burn tissue injury, which occurred (sometimes even a life-threatening situation).
    In pre-clinical model SC106, a compound derived from the Aloe Barbarossa plant, was found effective in treating burns, immediately stopping the damage on the surrounding tissue, detaining the stasis.

    Dental Bone Rejuvenation

    A dental implant is a titanium post, like an artificial tooth root, that is surgically positioned into the jawbone supporting restorations that resemble a tooth or group of teeth.
    Dental implants are fast becoming the preferred restoration for replacement of missing or extracted teeth or as supports for dentures, crowns and bridges. Successful dental implanting of the artificial root requires the jaw bone to rejuvenate so that it can provide sufficient basis for holding the implant in place and allowing the placement of the replacement tooth leveled to its neighboring teeth.

    Early studies in SC661, propelled by the company's many years of experience in bone rejuvenation using the DT56a complex, have developed a botanical complex from the soybean plant, which accelerates bone rejuvenation and significantly shortens the recovery period required in the dental implant process. SC661 was shown to encourage bone rejuvenation and thus, provide a more robust bone basis for the implant and provides a jaw bone recovery management strategy to be applied by dentists in preparations for applying dental implants.

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    Burn Management

    According to the American Burn Association, 500,000 cases of burns are handled by professional service providers each year in the United States, of whom about 40,000 are hospitalized. The number of minor and medium burns treated by US health and emergency services is estimated to be 2 million cases per year.

    An undesired common phenomenon in cases of burns is the formation of Stasis (cessation of blood flow) around the area of the burn, which occurs for the most part in events of 2nd degree burns extending over a large area and in all 3rd degree burns. The scientific explanation for this phenomenon is that this is a natural process in which the body recognizes the wound of the burn injury as a significant potential risk. For this reason, the skin tissue mortality becomes twice the area of the burn itself, creating significant damage beyond the original burn tissue injury, which occurred (sometimes even a life-threatening situation).
    In pre-clinical model SC106, a compound derived from the Aloe Barbarossa plant, was found effective in treating burns, immediately stopping the damage on the surrounding tissue, detaining the stasis.

    Read more

    Close

    Dental Bone Rejuvenation

    A dental implant is a titanium post, like an artificial tooth root, that is surgically positioned into the jawbone supporting restorations that resemble a tooth or group of teeth.
    Dental implants are fast becoming the preferred restoration for replacement of missing or extracted teeth or as supports for dentures, crowns and bridges. Successful dental implanting of the artificial root requires the jaw bone to rejuvenate so that it can provide sufficient basis for holding the implant in place and allowing the placement of the replacement tooth leveled to its neighboring teeth.

    Early studies in SC661, propelled by the company's many years of experience in bone rejuvenation using the DT56a complex, have developed a botanical complex from the soybean plant, which accelerates bone rejuvenation and significantly shortens the recovery period required in the dental implant process. SC661 was shown to encourage bone rejuvenation and thus, provide a more robust bone basis for the implant and provides a jaw bone recovery management strategy to be applied by dentists in preparations for applying dental implants.

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    Contact Us:
    Se-cure Pharmaceuticals Ltd.
    Head Office: 1 Haarava st., Airport City 7010000 Israel

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